Serum amyloid a protein level, and its significance in systemic lupus erythematosus patients
نویسنده
چکیده
Objective: To investigate The level of serum amyloid A protein (SAA) in systemic lupus erythematosus (SLE) patients and its importance in disease activity. Materials and Methods: Fortytwo female patients who satisfied four or more of the revised ACR criteria for SLE were included in this study. Fifteen healthy female subjects matched for age were included as controls. Disease activity was assessed by the systemic lupus activity measurement (SLAM) index. Serum amyloid A protein was measured by the particle enhanced nephelometry technique. Results: Serum amyloid A protein (SAA) levels in SLE patients (95.27±100.62 mg/l) were higher than in the controls (4.08+1.14 mg/l) and the difference was statistically significant. Correlation between the SAA level and some of the disease parameters revealed a statistically significant positive correlation with the SLAM index score, prednisone dose and C-reactive protein. No significant correlation was found with age, disease duration, C3, C4, total leucocytic count, ESR or hemoglobin. Serum AA was significantly higher among patients with lupus Egyptian Dermatology Online Journal Vol. 1 No 1:2, December 2005
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تاریخ انتشار 2009